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Spastic paraplegia - Paget disease of bone
1 associated gene
No signs/symptoms info
PROTEIN INTERACTIONS: 1
Narcolepsy-cataplexy
7 OMIM references -
8 associated genes
10 signs/symptoms
Spastic paraplegia - Paget disease of bone
Narcolepsy-cataplexy

VCP
(UniProt - OMIM)
 CTSH
(UniProt - OMIM)
HCRT
(UniProt - OMIM)
HLA-DQB1
(UniProt - OMIM)
HLA-DRB1
(UniProt - OMIM)
MOG
(UniProt - OMIM)
P2RY11
(UniProt - OMIM)
TNFSF4
(UniProt - OMIM)
ZNF365
(UniProt - OMIM)

INTERACTOME
ASSOCIATIONS
(click on a score value to see the evidence)
VCP
(0.63)
HLA-DRB1


Citations in the biomedical literature:


Spastic paraplegia - Paget disease of bone
VCP
Narcolepsy-cataplexy
CTSH HCRT HLA-DQB1 HLA-DRB1 MOG P2RY11
TNFSF4 ZNF365



Spastic paraplegia - Paget disease of bone
Narcolepsy-cataplexy

Synonym(s):
(no synonyms)

Synonym(s):
- Gélineau disease
Classification (Orphanet):
- Rare bone disease
- Rare developmental defect during embryogenesis
- Rare genetic disease
- Rare neurologic disease
Classification (Orphanet):
- Rare neurologic disease
Classification (ICD10):
(no data available)
Classification (ICD10):
- Diseases of the nervous system -
Epidemiological data:
Class of prevalence: <1 / 1 000 000
Average age onset: adulthood
Average age of death: -
Type of inheritance: autosomal dominant
Epidemiological data:
Class of prevalence: 1-5 / 10 000
Average age onset: adolescence / young
Average age of death: normal
Type of inheritance: unknown
External references:
No OMIM references
No MeSH references
External references:
7 OMIM references -
1 MeSH reference: D009290
Narcolepsy-cataplexy

Very frequent
- Delirium / hallucination
- Muscle weakness / flaccidity
- Sleep and vigilance disorders
- Somnolence / hypersomnia / parasomnia
- Troubles of memory / amnesia / hypermnesia

Frequent
- Abnormal eye movements / oculomotor disorder
- Anomalies of eyes and vision

Occasional
- Collapse / sudden death / cardiac arrest / cardiorespiratory arrest
- Generalized obesity
- Speech troubles / aphasia / dysphasia / echolalia / mutism / logorrhea / dysprosodia


Spastic paraplegia - Paget disease of bone

(no data available)